Sema4 Holdings Corp.

EDGAR

Annual consolidated revenue for 2025: about USD 427.5M, using the latest reported figures. The previous period, 2024, was about USD 305.5M.

Watchlist

Latest quarter

Revenue

114 million USD

2026 Q2 · USD

Exact inputs and evidence

Operating margin

-15.25%

2026 Q2 · %

Exact inputs and evidence
  • Operating Income: -17455000 USD Source
  • Revenue: 114440000 USD Source

Operating cash flow

-29 million USD

2026 Q2 · USD

Exact inputs and evidence
  • Operating Cash Flow: -61389000 USD Source
  • Operating Cash Flow: -32408000 USD Source

Free cash flow

-39.1 million USD

2026 Q2 · USD

Exact inputs and evidence
  • Operating Cash Flow: -61389000 USD Source
  • Operating Cash Flow: -32408000 USD Source
  • Capital Expenditure: 16567000 USD Source
  • Capital Expenditure: 6453000 USD Source
Cash and cash equivalents
60.3 million USD Source
Exact value

60317000 USD

Long-term debt including current maturities
100 million USD Source
Exact value

100000000 USD

Shares outstanding
29.8 million shares Source
Exact value

29803164 shares

Reported share-count change

3.81% · 1.1 million shares

Year-over-year change in reported shares. Splits, issuance and buybacks can affect this figure; it does not isolate employee compensation or economic dilution.

Exact inputs and evidence
  • 28708058 shares · 2025-06-30· Source
  • 29803164 shares · 2026-06-30· Source

Trailing twelve months

The four most recent complete quarters added together. This gives a full-year view that includes the latest quarterly results.

Revenue

454 million USD

2025-07-01 – 2026-06-30

Exact inputs and evidence
  • Revenue: 116743000 USD · 2025-07-01 – 2025-09-30 Source
  • Revenue: 427539000 USD · 2025-01-01 – 2025-12-31 Source
  • Revenue: 306550000 USD · 2025-01-01 – 2025-09-30 Source
  • Revenue: 102254000 USD · 2026-01-01 – 2026-03-31 Source
  • Revenue: 114440000 USD · 2026-04-01 – 2026-06-30 Source

Net income

-106 million USD

2025-07-01 – 2026-06-30

Exact inputs and evidence
  • Net income: -7635000 USD · 2025-07-01 – 2025-09-30 Source
  • Net income: -21021000 USD · 2025-01-01 – 2025-12-31 Source
  • Net income: -3355000 USD · 2025-01-01 – 2025-09-30 Source
  • Net income: -63316000 USD · 2026-01-01 – 2026-03-31 Source
  • Net income: -17740000 USD · 2026-04-01 – 2026-06-30 Source

Operating cash flow

-48.7 million USD

2025-07-01 – 2026-06-30

Exact inputs and evidence
  • Operating cash flow: 36369000 USD · 2025-01-01 – 2025-09-30 Source
  • Operating cash flow: 20602000 USD · 2025-01-01 – 2025-06-30 Source
  • Operating cash flow: 33279000 USD · 2025-01-01 – 2025-12-31 Source
  • Operating cash flow: 36369000 USD · 2025-01-01 – 2025-09-30 Source
  • Operating cash flow: -32408000 USD · 2026-01-01 – 2026-03-31 Source
  • Operating cash flow: -61389000 USD · 2026-01-01 – 2026-06-30 Source
  • Operating cash flow: -32408000 USD · 2026-01-01 – 2026-03-31 Source

Capital expenditure

27.1 million USD

2025-07-01 – 2026-06-30

Exact inputs and evidence
  • Capital expenditure: 14670000 USD · 2025-01-01 – 2025-09-30 Source
  • Capital expenditure: 8498000 USD · 2025-01-01 – 2025-06-30 Source
  • Capital expenditure: 19017000 USD · 2025-01-01 – 2025-12-31 Source
  • Capital expenditure: 14670000 USD · 2025-01-01 – 2025-09-30 Source
  • Capital expenditure: 6453000 USD · 2026-01-01 – 2026-03-31 Source
  • Capital expenditure: 16567000 USD · 2026-01-01 – 2026-06-30 Source
  • Capital expenditure: 6453000 USD · 2026-01-01 – 2026-03-31 Source

Free cash flow

-75.8 million USD

2025-07-01 – 2026-06-30

Exact inputs and evidence
  • Operating cash flow: 36369000 USD · 2025-01-01 – 2025-09-30 Source
  • Operating cash flow: 20602000 USD · 2025-01-01 – 2025-06-30 Source
  • Operating cash flow: 33279000 USD · 2025-01-01 – 2025-12-31 Source
  • Operating cash flow: 36369000 USD · 2025-01-01 – 2025-09-30 Source
  • Operating cash flow: -32408000 USD · 2026-01-01 – 2026-03-31 Source
  • Operating cash flow: -61389000 USD · 2026-01-01 – 2026-06-30 Source
  • Operating cash flow: -32408000 USD · 2026-01-01 – 2026-03-31 Source
  • Capital expenditure: 14670000 USD · 2025-01-01 – 2025-09-30 Source
  • Capital expenditure: 8498000 USD · 2025-01-01 – 2025-06-30 Source
  • Capital expenditure: 19017000 USD · 2025-01-01 – 2025-12-31 Source
  • Capital expenditure: 14670000 USD · 2025-01-01 – 2025-09-30 Source
  • Capital expenditure: 6453000 USD · 2026-01-01 – 2026-03-31 Source
  • Capital expenditure: 16567000 USD · 2026-01-01 – 2026-06-30 Source
  • Capital expenditure: 6453000 USD · 2026-01-01 – 2026-03-31 Source

Company performance

Up to ten complete financial years · consolidated figures

Includes later revisions to earlier periods. Annual charts exclude incomplete years.

Latest filing recorded: 2026-08-03.

Financial data available through: 2025-12-31.

Coverage by financial measure
  • Revenue: 8 of 11 periods available· newest 2025-12-31
  • Operating income: 8 of 11 periods available· newest 2025-12-31
  • Net income: 8 of 11 periods available· newest 2025-12-31
  • Operating cash flow: 8 of 11 periods available· newest 2025-12-31
  • Capital expenditure: 8 of 11 periods available· newest 2025-12-31
  • Total assets: 7 of 11 periods available· newest 2025-12-31
  • Total liabilities: 7 of 11 periods available· newest 2025-12-31
  • Current assets: 7 of 11 periods available· newest 2025-12-31
  • Current liabilities: 7 of 11 periods available· newest 2025-12-31
  • Cash and cash equivalents: 7 of 11 periods available· newest 2025-12-31
  • Long-term debt including current maturities: 6 of 11 periods available· newest 2025-12-31
  • Shares outstanding: 7 of 11 periods available· newest 2025-12-31

Coverage describes values retained in this snapshot. Missing values are not zero; loading limits are reported separately.

What changed year over year

Latest complete year compared with the corresponding period one year earlier. These are measured changes; they do not establish their business causes.

  • Revenue

    +40%

    Prior period

    USD 305.45 million

    –

    Current period

    USD 427.54 million

    –

    Exact inputs and evidence

    427539000 − 305450000 = 122089000 USD

    305450000 USD · 2024-01-01 – 2024-12-31

    Inspect prior input Prior source

    427539000 USD · 2025-01-01 – 2025-12-31

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  • Net income

    +USD 31.27 million

    Prior period

    −USD 52.29 million

    –

    Current period

    −USD 21.02 million

    –

    Exact inputs and evidence

    -21021000 − -52286000 = 31265000 USD

    -52286000 USD · 2024-01-01 – 2024-12-31

    Inspect prior input Prior source

    -21021000 USD · 2025-01-01 – 2025-12-31

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  • Operating cash flow

    +USD 61.78 million

    Prior period

    −USD 28.5 million

    –

    Current period

    USD 33.28 million

    –

    Exact inputs and evidence

    33279000 − -28496000 = 61775000 USD

    -28496000 USD · 2024-01-01 – 2024-12-31

    Inspect prior input Prior source

    33279000 USD · 2025-01-01 – 2025-12-31

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  • Capital expenditure

    +246.3%

    Prior period

    USD 5.49 million

    –

    Current period

    USD 19.02 million

    –

    Exact inputs and evidence

    19017000 − 5491000 = 13526000 USD

    5491000 USD · 2024-01-01 – 2024-12-31

    Inspect prior input Prior source

    19017000 USD · 2025-01-01 – 2025-12-31

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Where revenue goes

How a period’s revenue divides into costs and what remains as profit. Items marked Derived are calculated by subtraction from reported figures.

2025 2025-01-01 – 2025-12-31

  • Revenue USD 427.54 million 100% of revenue
  • Operating costs Derived USD 440.62 million 103% of revenue
  • Operating income −USD 13.08 million −3.1% of revenue
  • Tax, interest and other Derived USD 7.94 million 1.9% of revenue
  • Net income −USD 21.02 million −4.9% of revenue

Cash

  • Operating cash flow USD 33.28 million 7.8% of revenue
  • Capital expenditure USD 19.02 million 4.4% of revenue
  • Free cash flow Derived USD 14.26 million 3.3% of revenue

Share of revenue by period

  • Net income
  • Tax, interest and other
  • Operating costs
  • 2018 Operating loss: operating costs were 121% of revenue.
  • 2019 Operating loss: operating costs were 116% of revenue.
  • 2020 Operating loss: operating costs were 235% of revenue.
  • 2021 Operating loss: operating costs were 310% of revenue.
  • 2022 Operating loss: operating costs were 384% of revenue.
  • 2023 Operating loss: operating costs were 189% of revenue.
  • 2024 Operating loss: operating costs were 108% of revenue.
  • 2025 Operating loss: operating costs were 103% of revenue.
Values and sources
Revenue breakdown by annual reporting period
PeriodRevenueOperating costsOperating incomeTax, interest and otherNet incomeFree cash flowSource
2018 2018-01-01 – 2018-12-31133341000 162004000 Derived -28663000 -4763000 Derived -23900000 -26867000 Derived
Source
2019 2019-01-01 – 2019-12-31196174000 226587000 Derived -30413000 -709000 Derived -29704000 -30651000 Derived
Source
2020 2020-01-01 – 2020-12-31179322000 421316000 Derived -241994000 -654000 Derived -241340000 -117222000 Derived
Source
2021 2021-01-01 – 2021-12-31212195000 658344000 Derived -446149000 -200759000 Derived -245390000 -199834000 Derived
Source
2022 2022-01-01 – 2022-12-31234694000 902346000 Derived -667652000 -118672000 Derived -548980000 -326311000 Derived
Source
2023 2023-01-01 – 2023-12-31202566000 383162000 Derived -180596000 -4829000 Derived -175767000 -185397000 Derived
Source
2024 2024-01-01 – 2024-12-31305450000 328663000 Derived -23213000 29073000 Derived -52286000 -33987000 Derived
Source
2025 2025-01-01 – 2025-12-31427539000 440616000 Derived -13077000 7944000 Derived -21021000 14262000 Derived
Source

Amounts are exact, in USD.

Growth

Sales over time and how quickly they are changing.

Revenue

Revenue reported for each complete financial period.

USD 427.5M 2025
Revenue historyRevenue reported for each complete financial period. Values are shown by financial reporting period. Open Values and sources below for the exact observations and evidence.461.7M346.3M230.9M115.4M0.0201820222025
Values and sources
Revenue values and source evidence
PeriodSeriesValue(USD)Source evidence
2018Revenue133341000
2019Revenue196174000
2020Revenue179322000
2021Revenue212195000
2022Revenue234694000
2023Revenue202566000
2024Revenue305450000
2025Revenue427539000

Revenue growth

Change in revenue from the same financial period one year earlier.

40% 2025
Revenue growth historyChange in revenue from the same financial period one year earlier. Values are shown by financial reporting period. Open Values and sources below for the exact observations and evidence.56%37%19%-0%-19%201820222025
Values and sources
Revenue growth values and source evidence
PeriodSeriesValueSource evidence
2018Year over yearNo prior comparable period
2019Year over year47.1%
2020Year over year-8.6%
2021Year over year18.3%
2022Year over year10.6%
2023Year over year-13.7%
2024Year over year50.8%
2025Year over year40%

Profit and cash

How much revenue becomes profit, and how much cash operations generate.

Profit margins

Operating income, net income and free cash flow as a share of revenue.

Operating margin -3.1% 2025
Net margin -4.9% 2025
Free cash flow margin 3.3% 2025
Profit margins historyOperating income, net income and free cash flow as a share of revenue. Values are shown by financial reporting period. Open Values and sources below for the exact observations and evidence.26%-57%-141%-224%-308%201820222025
  • Operating margin
  • Net margin
  • Free cash flow margin
Values and sources
Profit margins values and source evidence
PeriodSeriesValueSource evidence
2018Operating margin-21.5%
2019Operating margin-15.5%
2020Operating margin-134.9%
2021Operating margin-210.3%
2022Operating margin-284.5%
2023Operating margin-89.2%
2024Operating margin-7.6%
2025Operating margin-3.1%
2018Net margin-17.9%
2019Net margin-15.1%
2020Net margin-134.6%
2021Net margin-115.6%
2022Net margin-233.9%
2023Net margin-86.8%
2024Net margin-17.1%
2025Net margin-4.9%
2018Free cash flow margin-20.1%
2019Free cash flow margin-15.6%
2020Free cash flow margin-65.4%
2021Free cash flow margin-94.2%
2022Free cash flow margin-139%
2023Free cash flow margin-91.5%
2024Free cash flow margin-11.1%
2025Free cash flow margin3.3%

Operating cash flow

Cash generated by the company’s normal business operations.

USD 33.3M 2025
Operating cash flow historyCash generated by the company’s normal business operations. Values are shown by financial reporting period. Open Values and sources below for the exact observations and evidence.61.5M-40.7M-142.9M-245.1M-347.3M201820222025
Values and sources
Operating cash flow values and source evidence
PeriodSeriesValue(USD)Source evidence
2018Operating cash flow-24684000
2019Operating cash flow-18728000
2020Operating cash flow-93128000
2021Operating cash flow-190434000
2022Operating cash flow-319155000
2023Operating cash flow-180147000
2024Operating cash flow-28496000
2025Operating cash flow33279000

Free cash flow

Operating cash flow minus capital expenditure for the same period and unit.

USD 14.3M 2025
Free cash flow historyOperating cash flow minus capital expenditure for the same period and unit. Values are shown by financial reporting period. Open Values and sources below for the exact observations and evidence.41.5M-57.3M-156.0M-254.8M-353.6M201820222025
Values and sources
Free cash flow values and source evidence
PeriodSeriesValue(USD)Source evidence
2018Free cash flow-26867000
2019Free cash flow-30651000
2020Free cash flow-117222000
2021Free cash flow-199834000
2022Free cash flow-326311000
2023Free cash flow-185397000
2024Free cash flow-33987000
2025Free cash flow14262000

Balance sheet

Liabilities and short-term ability to meet obligations at each period end.

Liabilities to assets

Total liabilities as a share of total assets.

41.2% 2025
Liabilities to assets historyTotal liabilities as a share of total assets. Values are shown by financial reporting period. Open Values and sources below for the exact observations and evidence.106%80%53%27%0%2018-12-3120222025
Values and sources
Liabilities to assets values and source evidence
PeriodSeriesValueSource evidence
2018-12-31Liabilities / assetsNot reportedNo source recorded
2019Liabilities / assets37%
2020Liabilities / assets98.3%
2021Liabilities / assets30%
2022Liabilities / assets48.3%
2023Liabilities / assets45.5%
2024Liabilities / assets41.5%
2025Liabilities / assets41.2%

Current assets to current liabilities

Current assets divided by current liabilities.

2.46× 2025
Current assets to current liabilities historyCurrent assets divided by current liabilities. Values are shown by financial reporting period. Open Values and sources below for the exact observations and evidence.5.16×3.87×2.58×1.29×0.00×2018-12-3120222025
Values and sources
Current assets to current liabilities values and source evidence
PeriodSeriesValueSource evidence
2018-12-31Current assets / current liabilitiesNot reportedNo source recorded
2019Current assets / current liabilities4.08×
2020Current assets / current liabilities2.37×
2021Current assets / current liabilities4.77×
2022Current assets / current liabilities1.47×
2023Current assets / current liabilities3.1×
2024Current assets / current liabilities3.61×
2025Current assets / current liabilities2.46×

Cash generation

Compare reported profit with operating cash and capital spending. Free cash flow is calculated as operating cash flow minus capital expenditure when both exact, consolidated amounts match the same period and unit.

Cash generation by annual reporting period
PeriodNet incomeOperating cash flowCapital expenditureFree cash flow
2018 2018-01-01 – 2018-12-31
−USD 23.9 million
Exact value

Exact value: -23900000 USD

2018-01-01 – 2018-12-31: -23900000 USD Inspect Net Income Open source
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−USD 24.68 million
Exact value

Exact value: -24684000 USD

2018-01-01 – 2018-12-31: -24684000 USD Inspect Operating Cash Flow Open source
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USD 2.18 million
Exact value

Exact value: 2183000 USD

2018-01-01 – 2018-12-31: 2183000 USD Inspect Capital Expenditure Open source
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−USD 26.87 million
Calculation and evidence

-24684000 − 2183000 USD

Exact free cash flow: -26867000 USD

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2019 2019-01-01 – 2019-12-31
−USD 29.7 million
Exact value

Exact value: -29704000 USD

2019-01-01 – 2019-12-31: -29704000 USD Inspect Net Income Open source
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−USD 18.73 million
Exact value

Exact value: -18728000 USD

2019-01-01 – 2019-12-31: -18728000 USD Inspect Operating Cash Flow Open source
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USD 11.92 million
Exact value

Exact value: 11923000 USD

2019-01-01 – 2019-12-31: 11923000 USD Inspect Capital Expenditure Open source
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−USD 30.65 million
Calculation and evidence

-18728000 − 11923000 USD

Exact free cash flow: -30651000 USD

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2020 2020-01-01 – 2020-12-31
−USD 241.34 million
Exact value

Exact value: -241340000 USD

2020-01-01 – 2020-12-31: -241340000 USD Inspect Net Income Open source
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−USD 93.13 million
Exact value

Exact value: -93128000 USD

2020-01-01 – 2020-12-31: -93128000 USD Inspect Operating Cash Flow Open source
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USD 24.09 million
Exact value

Exact value: 24094000 USD

2020-01-01 – 2020-12-31: 24094000 USD Inspect Capital Expenditure Open source
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−USD 117.22 million
Calculation and evidence

-93128000 − 24094000 USD

Exact free cash flow: -117222000 USD

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2021 2021-01-01 – 2021-12-31
−USD 245.39 million
Exact value

Exact value: -245390000 USD

2021-01-01 – 2021-12-31: -245390000 USD Inspect Net Income Open source
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−USD 190.43 million
Exact value

Exact value: -190434000 USD

2021-01-01 – 2021-12-31: -190434000 USD Inspect Operating Cash Flow Open source
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USD 9.4 million
Exact value

Exact value: 9400000 USD

2021-01-01 – 2021-12-31: 9400000 USD Inspect Capital Expenditure Open source
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−USD 199.83 million
Calculation and evidence

-190434000 − 9400000 USD

Exact free cash flow: -199834000 USD

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2022 2022-01-01 – 2022-12-31
−USD 548.98 million
Exact value

Exact value: -548980000 USD

2022-01-01 – 2022-12-31: -548980000 USD Inspect Net Income Open source
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−USD 319.16 million
Exact value

Exact value: -319155000 USD

2022-01-01 – 2022-12-31: -319155000 USD Inspect Operating Cash Flow Open source
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USD 7.16 million
Exact value

Exact value: 7156000 USD

2022-01-01 – 2022-12-31: 7156000 USD Inspect Capital Expenditure Open source
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−USD 326.31 million
Calculation and evidence

-319155000 − 7156000 USD

Exact free cash flow: -326311000 USD

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2023 2023-01-01 – 2023-12-31
−USD 175.77 million
Exact value

Exact value: -175767000 USD

2023-01-01 – 2023-12-31: -175767000 USD Inspect Net Income Open source
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−USD 180.15 million
Exact value

Exact value: -180147000 USD

2023-01-01 – 2023-12-31: -180147000 USD Inspect Operating Cash Flow Open source
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USD 5.25 million
Exact value

Exact value: 5250000 USD

2023-01-01 – 2023-12-31: 5250000 USD Inspect Capital Expenditure Open source
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−USD 185.4 million
Calculation and evidence

-180147000 − 5250000 USD

Exact free cash flow: -185397000 USD

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2024 2024-01-01 – 2024-12-31
−USD 52.29 million
Exact value

Exact value: -52286000 USD

2024-01-01 – 2024-12-31: -52286000 USD Inspect Net Income Open source
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−USD 28.5 million
Exact value

Exact value: -28496000 USD

2024-01-01 – 2024-12-31: -28496000 USD Inspect Operating Cash Flow Open source
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USD 5.49 million
Exact value

Exact value: 5491000 USD

2024-01-01 – 2024-12-31: 5491000 USD Inspect Capital Expenditure Open source
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−USD 33.99 million
Calculation and evidence

-28496000 − 5491000 USD

Exact free cash flow: -33987000 USD

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2025 2025-01-01 – 2025-12-31
−USD 21.02 million
Exact value

Exact value: -21021000 USD

2025-01-01 – 2025-12-31: -21021000 USD Inspect Net Income Open source
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USD 33.28 million
Exact value

Exact value: 33279000 USD

2025-01-01 – 2025-12-31: 33279000 USD Inspect Operating Cash Flow Open source
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USD 19.02 million
Exact value

Exact value: 19017000 USD

2025-01-01 – 2025-12-31: 19017000 USD Inspect Capital Expenditure Open source
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USD 14.26 million
Calculation and evidence

33279000 − 19017000 USD

Exact free cash flow: 14262000 USD

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Capital expenditure uses the canonical mapped positive-spending convention. A missing, ambiguous, incompatible, or negative-sign input is left blank. Values use the latest reported version.

Dataset coverage and company identifiers

Coverage reflects filings processed into this Fundies dataset; it does not imply every source filing is loaded.

35 filings · 3,746 latest values · 3,745 originally reported values

Dataset published . Source filing dates and reporting periods are shown separately.

Identifiers: 0001818331, 1818331, CMLF, WGS, edgar:1818331

Also known as CM LIFE SCIENCES, INC., CM Life Sciences, Inc., GeneDx Holdings Corp., Sema4 Holdings Corp.